Sweeney went to first base and eventually scored on a sacrifice fly, giving the Mariners a 1-0 lead, but he was replaced by Ken Griffey Jr. in the third inning.
A club official reported later in the game that Sweeney suffered a bruised big toe on his left foot.
Sweeney entered the series opener as one of Seattle's hottest hitters.
Since Aug. 13, when he was batting .228, the veteran has hit .400 (28-for-70) with six doubles, three home runs and 11 RBIs in 20 games.
Jim Street is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.