Griffey went 3-for-5 and drove in three runs, falling a triple short of the cycle. Griffey never has hit for the cycle, but he let it be known that if he came to bat in the ninth inning and got a hit, he would not stop running until he reached third.
But he was in the on-deck circle when Lopez, who also fell a triple short of the cycle, grounded into an inning-ending double play.
"My plan was go to third and not even touch the other two bags," Griffey said. "No reason to waste a whole lot of energy."
Griffey, who is fifth on the all-time home run list and the leader among active players, had said before the game that he was "getting better passes" at the ball.
"This is as good as I have seen him in a while," Mariners manager Don Wakamatsu said. "He stood in there with a lot of confidence tonight."
Jim Street is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.