Gutierrez was getting treatment all afternoon and during the game. Wedge hoped that, if needed, Gutierrez could at least serve as a pinch-hitter.
"Hopefully, we can get him back in there tomorrow," he said.
It's not certain when Gutierrez injured his groin or if it was the result of one incident.
"He's been feeling it the past couple days," Wedge said. "I don't think it helped when he went up on the wall the other day. He may have aggravated it a little more."
On Thursday night Gutierrez ran into the wall chasing down a double by Lance Berkman.
His injury comes at a time outfielder Michael Morse is sidelined with a fractured right pinkie finger and is unavailable for at least another five days. Outfielder Michael Saunders was placed on the disabled list April 10 with a sprained right shoulder.
The club has added Endy Chavez to the roster for depth, and if pressed, Wedge said he could use Robert Andino in the outfield.
Over the past two seasons Gutierrez has appeared in 132 of a possible 324 games due to four trips to the DL.
"You see his history. We just got to manage him the best we can," Wedge said. "We've been doing it all spring, which is what we have to do. That's why we have to give him periodic days off."
Bob Sherwin is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.