The White Sox rang up 10 hits and eight runs in five innings off Hernandez, who was making his last appearance before his Opening Day start on March 28 against the A's in the Tokyo Dome.
Hernandez had been strong all spring, sporting a 2-1 record and 1.38 ERA in three prior starts. But the White Sox touched him for three runs in the fourth, led by a two-run double by Lillibridge, then added four more in the fifth.
Hernandez threw 92 pitches, his longest start of the spring. He'll throw a couple of bullpen sessions in Tokyo, but has no more games before the Opening Day outing.
Hernandez said he felt fine, but chalked this up to Spring Training and said the main thing was getting his work in.
"They hit everything I threw," he said. "They were looking for pitches up and I got behind in counts. And when I threw the fastball, they hit it. I threw good pitches. I threw nasty pitches. I don't know. For real, I don't know."
Ichiro Suzuki, batting in his new No. 3 slot in Seattle's order, ripped his second home run of the spring with a solo shot in the first inning off White Sox starter Eric Stults.
Stults wound up allowing two runs on five hits in four innings for the White Sox, who improved to 6-11 in Cactus League play.
Alexei Ramirez had three hits and three RBIs, while Fukudome, Lillibridge and Paul Konerko each had two hits for the White Sox. Rookie designated hitter Jesus Montero had a pair of singles for Seattle.
Alex Liddi drove in three runs as the Mariners tallied six runs in the final two frames.Up next for Mariners: The team boards a charter for Tokyo at 1 p.m. on Thursday, landing 13 hours later -- about 5 p.m. in Japan -- to kick off a week-long trip that will conclude with the two-game regular-season series with the A's on March 28-29. The next game for Seattle will be a an exhibition against the Hanshin Tigers, with Hector Noesi making the start for the Mariners. That game will be broadcast live Saturday on Gameday Audio at 8:06 p.m. PT.