Wells has felt ill the past two days and said after the game he'll remain in Seattle to undergo further medical tests rather than accompany the team on its upcoming seven-day road trip.
Wells, one of four players obtained in the July 30 trade with the Tigers for Doug Fister and David Pauley, was scratched from Saturday's contest shortly before game time and didn't play again Sunday.
After a hot start with Seattle, he's just 3-for-45 since Aug. 22, though he did hit a home run in his last game Friday against the Rangers.
Smoak injured a groin muscle running the bases on Wednesday but did some pregame work Sunday and "hopefully will be able to be back in there [Monday]," according to manager Eric Wedge.
Ryan could be out several more days with tightness in his upper back and neck, the same problem that sidelined him on Wednesday against the Yankees after he was pulled from Tuesday's game.
"He's walking around like a mummy, if mummies can walk," said Wedge.
Wedge feels the late run of health problems is a sign that many of the young players need to get themselves in better shape for the long haul of a Major League season.
"A lot of these guys are going to have to do better in the offseason," he said. "We're going to have a lot of discussions with a lot of these guys on the work and the time and effort and discipline they're going to have to commit to to be able to come out here and play 150 games."
With 15 rookies on the roster, some of that is just getting used to the longer season.
"It is part of the process," Wedge said. "Everybody can talk about it all they want, but until you go through it and live it and feel it mentally, physically, emotionally, it's hard to really understand and appreciate.
"That's why we've got to keep running these guys out there, so they can feel just how much harder it is today and yesterday or next week vs. today."
Wedge will meet with each player before season's end to discuss their offseason work program.
"I've got a clear view of everybody with regard to what I want them to do this winter," he said. "Look what Mike Carp did with his body this offseason. You think that helped him this year? Are you kidding me? Things just don't happen by accident. We'll find out how bad they want it."