After going injury-free for his entire career, Smoak has injured his left thumb, right thumb and nose all this season. During Wednesday's 2-1 win over New York, the injury bug was back.
Smoak left the game after the third inning due to a mild right groin strain. He was held out of Friday's series opener against Texas and is day to day.
"I know he's frustrated about not playing today and we all want him in there," manager Eric Wedge said. "But it is what it is. You got to listen to your body and hopefully we'll get him back in there tomorrow or the next day."
After enjoying some success at the plate earlier this season, Smoak began struggling and hit .226 in June and just .141 in July. Then, due to several injuries, he had just six at-bats in August.
But the 24-year-old first baseman has bounced back nicely this month. He's hitting .326 (14-for-43) with two homers and six RBIs and appears to be finishing off the 2011 season on a bright note.