The 24-year old came out for batting practice early on Saturday, and something just wasn't feeling right.
"It was weird," he said. "Something I ate, I don't know what it was. I had a steak sandwich [on Saturday], and something wasn't sittin' right."
So he came into the clubhouse before batting practice even ended and was scratched from the lineup. But Smoak, who is tied for the team lead with 12 homers, still saw time on the field. He came in as a pinch-hitter in the seventh inning, with runners at second and third and his team down two runs.
The South Carolina native was hit by a Randy Choate pitch to load the bases, but Ichiro Suzuki grounded out to end the inning and any chance at a Mariners comeback.
"He's a tough kid," Seattle manager Eric Wedge said of Smoak. "He came out here and worked through it. We knew we'd have one shot at him, and felt pretty good about the shot we had. But it didn't work out."
The switch-hitting first baseman felt better on Sunday, though, and started at first base in the series finale, while hitting in the four-hole.