That has forced the entire Mariners rotation to make one adjustment after another, and Ramirez believes he finally has gotten himself into a groove.
He'll be pitching on five days' rest for the second time and it worked so well the last time that he held the Royals to one earned run over seven innings in the Mariners' 7-4 victory at Safeco Field.
He might need a carbon copy of that game against the Red Sox, who lead the American League East and have right-hander Daisuke Matsuzaka on the mound for Thursday night's makeup game.
The Mariners get their second look at Matsuzaka in the past three weeks. They defeated him 3-0 on April 11 behind right-hander Felix Hernandez.
"He's a good pitcher and has a lot of weapons," Mariners left fielder Raul Ibanez said. "We've seen him once, but by the same token, he has seen us once, too. It's going to be a battle."
SEA: LHP Horacio Ramirez (2-1, 4.41 ERA)
Ramirez lists Fenway Park as one of the stadiums he most wants to pitch in, and he gets that opportunity (weather permitting) in the makeup of a game that was rained out on April 12. Ramirez has been outstanding in two of his three starts, holding the Rangers to one earned run over six innings on April 15 and the Royals to one run six days ago. He never has faced the Red Sox.
BOS: LHP Daisuke Matsuzaka (3-2, 4.36 ERA)
One of Matsuzaka's two losses this season was administered by the Mariners, who defeated him 3-0 behind now-injured right-hander Felix Hernandez on April 11 at Fenway Park. Matsuzaka held fellow Japanese star Ichiro Suzuki hitless in three at-bats.
Player to watch
Mariners catcher Kenji Johjima helped spoil Matsuzaka's home debut. He doubled in the second inning to set up the game's first run and doubled again in the sixth.
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Official game notes
1000 AM KOMO;
Friday: Mariners (RHP Cha Seung Baek, 0-0, 4.22) at Yankees (LHP Kei Igawa, 2-1, 6.08), 4:05 p.m. PT
Saturday: Mariners (RHP Jeff Weaver, 0-4, 18.26) at Yankees (RHP Chien-Ming Wang, 0-2, 5.84), 12:55 p.m. PT
Monday: Mariners (LHP Jarrod Washburn 2-2, 2.88) at Yankees (TBA), 4:05 p.m. PT