Gutierrez, on the 15-day disabled list, worked out with the Mariners for three days last week and then headed to California over the weekend with the hope of beginning a Minor League rehabilitation assignment with the High Desert Mavericks.
But the digestive tract trouble that has plagued him returned before he could get back on the field, and the Mariners decided further steps need to be taken before he's cleared to play.
"Franklin is going to go to the Mayo Clinic tomorrow and get looked at up there," said Seattle manager Eric Wedge. "We don't have anything scheduled for him beyond that."
Gutierrez began having difficulties with his stomach midway through last season. He went on to win his first American League Gold Glove Award, though his offensive numbers tailed off in the second half.
The 28-year-old played just nine Cactus League games this spring before the club decided further tests were necessary. Gutierrez said last week he'd lost 15 pounds, but at that time, he was feeling better and able to eat normally again.
That changed in the interim, and the club will look to the Mayo Clinic for answers.