Pitching on the road hasn't agreed with the 43-year-old left-hander as he's gone 2-4 with a 5.52 ERA.
At Safeco Field, Moyer is 3-4 with a 2.81 ERA.
The Mariners are home for six games -- three against Boston and three more against the Toronto Blue Jays before embarking on a six-game road swing to Cleveland and Baltimore.
The Mariners are coming off a 2-4 road trip to Toronto and New York, though all four losses were by two runs or less -- three in extra innings.
SEA: LHP Jamie Moyer (5-8, 3.75 ERA)
Moyer hasn't fared well against the Red Sox in his career, going 6-10 with a 6.39 ERA in 21 games. He's 0-1 with a 3.00 ERA against Boston this season.
BOS: RHP Kyle Snyder (1-1, 10.03)
Snyder was claimed off waivers from Kansas City in June. He's only made two starts with the Red Sox after sporting a 22.50 ERA in one game with the Royals.
Players to watch
In his first series against the Red Sox, Seattle rookie catcher Kenji Johjima hit .455 in the four-game series, going 5-for-11 with an RBI.
On the Internet
Official game notes
KOMO 1000-AM, KTFH 1680-AM (Español)
Saturday: Red Sox (TBA) at Mariners (RHP Felix Hernandez, 8-8, 4.89), 1:05 p.m. PT
Sunday: Red Sox (LHP Jon Lester, 5-0, 2.38) at Mariners (LHP Jarrod Washburn, 4-10, 4.41), 1:05 p.m. PT
Corey Brock is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.