Runge was taken from U.S. Cellular Field to Rush University Medical Center in Chicago for further observation, and he was alert when he left.
"I felt bad for Brian," said Seattle catcher Josh Bard, who was behind the plate when Runge got hit. "You could tell that he had his bell rung pretty bad.
"Give it to him. He tried to stay in the game, but he was a little wobbly. I think it's good that they got him out of there. I hope he's all right, because it is no fun when you get smoked."
Second-base umpire Hunter Wendelstedt replaced Runge behind the plate, with the rest of the game being worked by Wendelstedt, Jerry Layne and Mike Muchlinski. The game was delayed for 10 minutes during the change, with the Mariners leading 5-3.
Scott Merkin is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.